RESOURCE OVERVIEW

Lyophilization is a common method for stabilizing parenteral drugs with poor solution stability. Beyond formulation and process development, a robust container-closure (c/c) system is essential to ensure the success of the lyophilized product. Pharmaceutical rubber closures play a critical role in preserving the drug’s integrity by acting as barriers against moisture, air, and oxygen. During lyophilization, stoppers are partially placed on vials before being fully stoppered under a predetermined vacuum level at the end of the process. Afterward, the vials are removed from the lyophilizer, capped, and sealed to maintain sterility.

In this whitepaper learn more from the Simtra BioPharma Solutions team on the Factors To Consider While Selecting Stoppers For Lyophilized Vials.

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